Pemiscot County is located in the southeastern part of Missouri, bordered by the Mississippi River to the east. It was established in 1851 and is known for its agricultural activities, particularly in cotton and soybean farming. The county seat is Caruthersville, which serves as the main hub for local government and commerce. The county features a mix of rural landscapes and small towns, with a population that reflects its agricultural roots. Pemiscot County is also home to several parks and recreational areas, providing opportunities for outdoor activities such as fishing and hiking along the river.