The PML gene (Promyelocytic Leukemia gene) is a human gene located on chromosome 15. It encodes a protein that plays a crucial role in regulating cell growth and apoptosis, which is the process of programmed cell death. The PML protein is involved in various cellular functions, including DNA repair and the response to stress. Mutations or alterations in the PML gene are associated with certain types of cancer, particularly acute promyelocytic leukemia (APL). In APL, a fusion protein called PML-RARA is formed, disrupting normal cell function and leading to the accumulation of immature blood cells. Understanding the PML gene is essential for developing targeted therapies for related cancers.