PML protein, or promyelocytic leukemia protein, is a crucial component of the cell that plays a significant role in regulating various cellular processes, including apoptosis (programmed cell death) and the response to stress. It is primarily found in the nucleus of cells and is involved in the formation of PML nuclear bodies, which are structures that help organize proteins and RNA within the nucleus. PML protein is best known for its association with acute promyelocytic leukemia (APL), a type of cancer. In APL, a genetic mutation leads to the production of a fusion protein that disrupts the normal function of PML, contributing to uncontrolled cell growth. Understanding PML protein's functions and interactions is essential for developing targeted therapies for APL and other related conditions.