Nogo-A is a protein that plays a crucial role in the nervous system, particularly in the development and regeneration of neurons. It is part of the Nogo family of proteins, which are known to inhibit nerve growth. Nogo-A is primarily expressed in the oligodendrocytes, the cells that produce myelin, which insulates nerve fibers and enhances signal transmission. Research has shown that Nogo-A can prevent the regeneration of damaged nerves, making it a significant factor in conditions like spinal cord injuries and multiple sclerosis. Scientists are exploring ways to block Nogo-A's effects to promote nerve repair and improve recovery outcomes for patients with neurological disorders.