Neonatal-Onset Multisystem Inflammatory Disease (NOMID) is a rare genetic condition that affects newborns. It is characterized by widespread inflammation in multiple organs, including the skin, joints, and central nervous system. This condition is caused by mutations in the NLRP3 gene, which plays a crucial role in the body's immune response. Symptoms of NOMID can include fever, rash, and joint pain, often leading to serious complications if not treated. Early diagnosis and management are essential to improve outcomes. Treatments may involve medications that reduce inflammation and suppress the immune system, helping to control the disease's effects on the body.