The Nashville, Chattanooga and St. Louis Railway (NC&StL) was a significant American railroad that operated primarily in the southeastern United States. Established in the 1850s, it connected major cities like Nashville, Chattanooga, and St. Louis, facilitating the movement of goods and passengers across the region. The railway played a crucial role in the economic development of the areas it served. In 1957, the NC&StL was merged into the Louisville and Nashville Railroad, marking the end of its independent operations. The railway's legacy continues to influence transportation and commerce in the southeastern U.S., with remnants of its routes still visible today.