Multifactorial diseases are health conditions caused by a combination of multiple factors, including genetic, environmental, and lifestyle influences. Examples of these diseases include diabetes, heart disease, and asthma. Unlike single-gene disorders, multifactorial diseases arise from the interplay of various elements, making them complex and often challenging to predict. The risk of developing a multifactorial disease can be influenced by family history, diet, physical activity, and exposure to toxins. Understanding these factors can help in prevention and management strategies. Research continues to explore how these elements interact to contribute to the onset and progression of these diseases.