Missouri State Route 21 is a north-south highway located in the state of Missouri. It stretches approximately 90 miles, connecting the city of De Soto in the north to Fredericktown in the south. The route serves as a vital link for local communities and provides access to various recreational areas. The highway passes through several counties, including Jefferson County and Madison County. Along its path, travelers can enjoy scenic views of the Ozark Mountains and access attractions such as Hawn State Park. Route 21 is an essential roadway for both residents and visitors exploring the region.