Missouri State Route 72 is a state highway located in the southeastern region of Missouri. It runs approximately 40 miles, connecting the city of Cape Girardeau to Poplar Bluff. The route primarily serves as a vital link for local traffic and provides access to various communities along its path. The highway features a mix of rural and suburban landscapes, with several intersections and connections to other major roads. It is an important route for residents and travelers, facilitating commerce and transportation in the area. Additionally, Route 72 is maintained by the Missouri Department of Transportation.