Missouri State Route 100 is a state highway located in the central part of Missouri. It spans approximately 50 miles, connecting the cities of Washington and Cuba. The route primarily runs east-west and serves as an important thoroughfare for local traffic and commerce. The highway passes through several small towns and rural areas, providing access to various amenities and attractions. It intersects with other major roads, enhancing connectivity within the region. Missouri State Route 100 is maintained by the Missouri Department of Transportation and plays a vital role in the state's transportation network.