Mission San Isidro is a historic Spanish mission located in California, founded in 1806. It was established by Franciscan missionaries to spread Christianity among the local Native American population, particularly the Kumeyaay people. The mission played a significant role in the cultural and agricultural development of the region. Today, the site is recognized for its historical importance and is part of California's mission trail. Visitors can explore the mission's architecture, gardens, and artifacts that reflect the life and work of the missionaries and the indigenous communities during the Spanish colonial period.