Methyl-CpG-Binding Proteins (MeCPs) are a family of proteins that specifically bind to methylated DNA, particularly at CpG dinucleotides. They play a crucial role in gene regulation by recognizing and interacting with methylated regions of the genome, which can lead to the repression of gene expression. This binding is essential for maintaining cellular identity and regulating developmental processes. One of the most studied members of this family is MeCP2, which is vital for normal brain function. Mutations in the MeCP2 gene are associated with Rett syndrome, a neurodevelopmental disorder that primarily affects females. Understanding these proteins helps researchers explore their roles in various biological processes and diseases.