Rett syndrome is a rare genetic disorder that primarily affects girls and is caused by mutations in the MECP2 gene. It typically appears between 6 months and 2 years of age, after a period of normal development. Symptoms include a loss of purposeful hand skills, difficulties with walking, and challenges in communication. As the condition progresses, individuals may experience repetitive hand movements, seizures, and problems with coordination. While there is currently no cure for Rett syndrome, early intervention and supportive therapies can help improve quality of life and manage symptoms.