Metal homeostasis refers to the regulation of metal ions within biological systems to maintain optimal levels for cellular function. Essential metals, such as iron, copper, and zinc, play critical roles in various biochemical processes, including enzyme function and electron transport. However, excess or deficiency of these metals can lead to toxicity or disease. Cells utilize specific proteins, such as metal transporters and chaperones, to control the uptake, storage, and distribution of metal ions. This balance is crucial for processes like metabolism and cell signaling. Disruptions in metal homeostasis can contribute to conditions such as neurodegenerative diseases and anemia.