Copper homeostasis refers to the regulation of copper levels in the body to maintain health. Copper is an essential trace element that plays a vital role in various biological processes, including energy production, iron metabolism, and the functioning of the nervous system. The body must balance copper intake from food and supplements with its excretion to prevent toxicity or deficiency. The liver is the primary organ responsible for copper homeostasis. It helps store excess copper and releases it into the bloodstream as needed. Proteins such as ceruloplasmin and metallothionein are crucial for transporting and storing copper, ensuring that cells receive the right amount for their functions while preventing harmful accumulation.