"Medici: Masters of Florence" is a historical drama series that explores the rise of the Medici family, a powerful banking dynasty in Renaissance Florence. The show highlights their influence on art, politics, and culture during the 15th century, showcasing key figures like Cosimo de' Medici and Lorenzo de' Medici. The series delves into the family's struggles against rivals and their efforts to maintain power while supporting renowned artists such as Leonardo da Vinci and Michelangelo. Through political intrigue and personal relationships, it illustrates the Medici's significant role in shaping the history of Florence and the broader Italian Renaissance.