MPL Mutation refers to changes in the MPL gene, which provides instructions for making a protein involved in blood cell production. This mutation can lead to various blood disorders, including essential thrombocythemia and primary myelofibrosis, where the body produces too many platelets or has abnormal blood cell formation. The presence of an MPL Mutation can be detected through genetic testing, helping doctors diagnose and manage these conditions. Understanding this mutation is crucial for developing targeted therapies and improving patient outcomes in those affected by related blood disorders.