Long-Term Depression (LTD) is a process in the brain that weakens the connections between neurons, or nerve cells. This reduction in synaptic strength occurs after certain patterns of activity, helping to fine-tune and refine neural circuits. LTD is essential for learning and memory, as it allows the brain to forget unnecessary information and make room for new experiences. This mechanism is the opposite of Long-Term Potentiation (LTP), which strengthens synaptic connections. Both LTD and LTP are crucial for processes like learning, memory formation, and neuroplasticity, enabling the brain to adapt and respond to new information throughout life.