Kuru Disease is a rare and fatal neurodegenerative disorder that was primarily found among the Fore people of Papua New Guinea. It is caused by prions, which are misfolded proteins that lead to brain damage. Symptoms include tremors, loss of coordination, and severe psychological changes. The disease was linked to the practice of ritualistic cannibalism, where the brain of deceased individuals was consumed. The transmission of Kuru occurs through the ingestion of infected human tissue. As a result of public health efforts and the cessation of cannibalistic practices, the incidence of Kuru has significantly declined. There is currently no cure, and the disease is always fatal.