Creutzfeldt-Jakob Disease (CJD) is a rare and fatal brain disorder caused by misfolded proteins called prions. These prions lead to the degeneration of brain tissue, resulting in severe neurological symptoms. Common signs include memory loss, personality changes, and difficulties with movement and coordination. CJD can occur in several forms, including sporadic, hereditary, and acquired. The sporadic type is the most common and occurs without any known cause. The disease progresses rapidly, typically leading to severe disability and death within a year of symptom onset. There is currently no cure or effective treatment for CJD.