KRT1, or keratin 1, is a protein that plays a crucial role in the structure and function of the skin. It is a member of the keratin family, which consists of fibrous proteins that provide strength and resilience to epithelial cells. KRT1 is primarily expressed in the upper layers of the epidermis, contributing to the formation of the skin barrier. Mutations in the KRT1 gene can lead to various skin disorders, such as ichthyosis and palmoplantar keratoderma. These conditions are characterized by abnormal skin growth and thickening, affecting the skin's appearance and function. Understanding KRT1 is essential for developing treatments for these genetic skin diseases.