Junctional Epidermolysis Bullosa (JEB) is a rare genetic skin disorder characterized by fragile skin that blisters easily. It occurs due to mutations in genes responsible for anchoring the outer layer of skin, the epidermis, to the underlying layer, the dermis. This condition can lead to severe skin damage, especially in areas subjected to friction or trauma. JEB is typically inherited in an autosomal recessive manner, meaning both parents must carry a copy of the mutated gene for their child to be affected. Symptoms can vary in severity, and while there is no cure, treatment focuses on wound care and preventing infections to improve the quality of life for those affected.