Infanta Isabel was a Spanish royal born on November 22, 1621, as the daughter of King Philip IV of Spain and Mariana of Austria. She was a member of the House of Habsburg and held the title of Infanta, which is a title for daughters of the reigning monarch. Isabel was known for her beauty and was often depicted in paintings by famous artists like Diego Velázquez. Isabel's life was marked by political alliances, as she was engaged to Ferdinand III of the Holy Roman Empire but died young at the age of 16 in 1637. Her untimely death was a significant loss for the Spanish royal family, as her marriage was intended to strengthen ties between Spain and the Holy Roman Empire.