Iduronate-2-sulfatase is an enzyme that plays a crucial role in the breakdown of certain complex carbohydrates known as glycosaminoglycans. Specifically, it helps to degrade heparan sulfate and dermatan sulfate, which are important for various biological functions in the body. Deficiency of Iduronate-2-sulfatase leads to a genetic disorder called Mucopolysaccharidosis type II (MPS II), also known as Hunter syndrome. This condition results in the accumulation of glycosaminoglycans in tissues, causing various health issues, including developmental delays and organ dysfunction.