The Hypothalamic-Pituitary-Adrenal (HPA) Axis is a complex system that plays a crucial role in the body's response to stress. It involves three key components: the hypothalamus, the pituitary gland, and the adrenal glands. When the body perceives stress, the hypothalamus releases corticotropin-releasing hormone (CRH), which signals the pituitary gland to produce adrenocorticotropic hormone (ACTH). This hormone then stimulates the adrenal glands to release cortisol, a hormone that helps manage stress. Cortisol has various effects on the body, including increasing blood sugar levels and suppressing the immune system. The HPA axis is essential for maintaining homeostasis, but chronic activation due to prolonged stress can lead to health issues such as anxiety, depression, and other disorders. Understanding the HPA axis helps researchers develop better treatments for stress-related conditions.