Hypoadrenalism, also known as adrenal insufficiency, occurs when the adrenal glands do not produce enough hormones, particularly cortisol. This condition can lead to symptoms such as fatigue, weight loss, low blood pressure, and skin changes. It can be caused by autoimmune diseases, infections, or certain medications. There are two main types of hypoadrenalism: primary and secondary. Primary hypoadrenalism, or Addison's disease, results from damage to the adrenal glands, while secondary hypoadrenalism is due to insufficient stimulation from the pituitary gland. Diagnosis typically involves blood tests and imaging studies to assess hormone levels and gland function.