The House of Osuna is a noble family from Spain, known for its historical significance and influence, particularly in the region of Andalusia. Established in the late 15th century, the family gained prominence through various titles and lands, including the Duchy of Osuna. Throughout the centuries, the House of Osuna played a vital role in Spanish politics and culture, contributing to the arts and sciences. Members of the family were patrons of notable figures, such as the painter Francisco de Goya, and they held significant positions in the Spanish court, reflecting their enduring legacy.