The House of Mendoza is a prominent noble family from Spain, particularly known for its influence during the late Middle Ages and the Renaissance. Originating in the region of Castile, the family played a significant role in the political and military affairs of the time, producing several notable figures, including Duke of the Infantado and Cardinal Mendoza. Members of the House of Mendoza were often involved in the royal court and held various titles and lands. Their legacy includes contributions to art, culture, and architecture, with many family members serving as patrons of the Spanish Renaissance and supporting the development of Spanish literature.