Histamine Intolerance occurs when the body has difficulty breaking down histamine, a compound involved in immune responses, digestion, and the central nervous system. This can happen due to a deficiency in the enzyme diamine oxidase (DAO), which is responsible for metabolizing histamine. As a result, histamine levels can build up, leading to various symptoms. Common symptoms of histamine intolerance include headaches, skin rashes, digestive issues, and respiratory problems. These symptoms can often be mistaken for allergies or other conditions. Managing histamine intolerance typically involves dietary changes to reduce histamine-rich foods and support overall health.