HERC1, or Hect domain and RCC1-like domain-containing protein 1, is a gene that encodes a protein involved in various cellular processes, including protein ubiquitination. This process is essential for regulating protein degradation, signaling, and cell cycle progression. HERC1 is part of the HERC family of proteins, which are characterized by their HECT (Homologous to the E6-AP Carboxyl Terminus) domain. The HERC1 protein is primarily expressed in the brain and plays a role in neuronal function. Mutations or dysregulation of HERC1 have been linked to certain diseases, highlighting its importance in maintaining cellular health and function. Understanding HERC1 can provide insights into its potential implications in neurodegenerative disorders and other health conditions.