HERC3, or Hect domain and RLD 3, is a protein that plays a crucial role in cellular processes, particularly in the regulation of protein degradation. It is part of the HERC family of proteins, which are known for their involvement in the ubiquitin-proteasome system, a pathway that helps control the levels of various proteins within cells. This protein is encoded by the HERC3 gene located on chromosome 22 in humans. Research has shown that HERC3 may influence various biological functions, including immune responses and cell signaling, making it a subject of interest in studies related to diseases and cellular health.