Extrusion-spheronization is a pharmaceutical process used to create spherical pellets from powdered materials. It involves two main steps: extrusion, where the powder is forced through a die to form long strands, and spheronization, where these strands are cut and rounded into small pellets. This method helps improve the flow properties and uniformity of the final product. The resulting pellets can enhance drug release profiles and improve the stability of the formulation. Extrusion-spheronization is commonly used in the production of controlled-release medications, making it a valuable technique in the pharmaceutical industry for optimizing drug delivery systems.