Expedition 46 was a mission to the International Space Station (ISS) that launched on December 15, 2015. This expedition was part of a series of long-duration missions aimed at conducting scientific research and technology demonstrations in microgravity. The crew included astronauts from NASA, Roscosmos, and ESA. During Expedition 46, the crew conducted various experiments in fields such as biology, physics, and Earth science. They also performed maintenance tasks on the ISS and participated in educational outreach activities to engage the public in space exploration. The mission concluded with the return of the crew on June 30, 2016.