Expedition 45 was a mission to the International Space Station (ISS) that took place from September 2014 to March 2015. It involved a crew of six astronauts and cosmonauts who conducted various scientific experiments and technology demonstrations in microgravity. The crew included NASA astronauts Scott Kelly and Kimiya Yui from JAXA, along with ESA astronaut Samantha Cristoforetti. They focused on research in fields such as biology, physics, and Earth science, contributing to our understanding of life in space and preparing for future long-duration missions.