The Epithelial Sodium Channel (ENaC) is a protein found in the membranes of epithelial cells, which line various organs and structures in the body. ENaC plays a crucial role in regulating sodium balance and fluid homeostasis by allowing sodium ions to enter cells from the surrounding environment. This process is essential for maintaining blood pressure and overall electrolyte balance. ENaC is primarily located in the kidneys, lungs, and salivary glands. Its activity is influenced by hormones such as aldosterone, which increases sodium reabsorption in the kidneys. Dysregulation of ENaC can lead to conditions like hypertension and cystic fibrosis.