ETS transcription factors are a family of proteins that play a crucial role in regulating gene expression. They bind to specific DNA sequences, influencing the transcription of target genes involved in various biological processes, including cell growth, differentiation, and development. These factors are characterized by a conserved ETS DNA-binding domain, which allows them to attach to DNA and modulate the activity of other proteins. ETS transcription factors are important in both normal cellular functions and in the progression of certain diseases, such as cancer, where their activity can become dysregulated.