The ETS DNA-binding domain is a specific protein structure found in a family of transcription factors known as ETS transcription factors. This domain enables these proteins to bind to specific DNA sequences, thereby regulating gene expression. The ETS domain typically consists of about 85 amino acids and is characterized by a winged-helix structure that facilitates its interaction with DNA. These transcription factors play crucial roles in various biological processes, including cell growth, differentiation, and development. Mutations or dysregulation of ETS transcription factors can be associated with several diseases, including cancer, highlighting their importance in maintaining normal cellular functions.