The Duke of Mayenne was a prominent French nobleman during the late 16th century, known for his role in the French Wars of Religion. Born in 1550, he was a member of the House of Guise and a key figure in the Catholic League, which opposed Protestant forces in France. His leadership was marked by military engagements and political maneuvering. Mayenne's most notable conflict was against Henry IV of France, who sought to unify the country. Despite his efforts, Mayenne ultimately faced defeat, leading to the decline of the Catholic League's influence. He died in 1611, leaving a legacy intertwined with the turbulent history of France during that era.