Dry granulation
Dry granulation is a process used in the pharmaceutical and food industries to create granules from fine powders without the use of liquid binders. This method typically involves compacting the powder into larger pieces, known as agglomerates, using a machine called a roller compactor. The resulting material is then broken down into granules of a desired size.
This technique is beneficial for materials sensitive to moisture or heat, as it avoids the use of solvents. Dry granulation helps improve the flow properties and compressibility of powders, making it easier to handle and process in the production of tablets and other solid dosage forms.