Cyclooxygenases, commonly known as COX, are enzymes that play a crucial role in the conversion of fatty acids into prostaglandins, which are important signaling molecules in the body. There are two main types of cyclooxygenases: COX-1 and COX-2. COX-1 is generally involved in maintaining normal physiological functions, such as protecting the stomach lining and supporting platelet function, while COX-2 is primarily associated with inflammation and pain. These enzymes are significant in the context of various medical conditions, including arthritis and cardiovascular diseases. Nonsteroidal anti-inflammatory drugs (NSAIDs), like ibuprofen and aspirin, work by inhibiting cyclooxygenases, thereby reducing pain and inflammation. Understanding the functions of cyclooxygenases helps in developing targeted therapies for managing pain and inflammatory disorders.