COX, or cyclooxygenase, is an enzyme that plays a crucial role in the body's inflammatory response. It exists in two main forms: COX-1 and COX-2. COX-1 is involved in maintaining normal physiological functions, such as protecting the stomach lining and supporting platelet function, while COX-2 is primarily expressed during inflammation and is responsible for producing pain and fever. Inhibitors of COX, known as NSAIDs (non-steroidal anti-inflammatory drugs), are commonly used to relieve pain and reduce inflammation. These medications work by blocking the action of COX enzymes, thereby decreasing the production of inflammatory substances. Examples of NSAIDs include ibuprofen and aspirin.