Cx33, also known as connexin 33, is a type of protein that forms gap junctions between cells. These gap junctions allow for direct communication and the transfer of small molecules and ions between adjacent cells, playing a crucial role in maintaining tissue homeostasis and coordinating cellular activities. Cx33 is primarily expressed in the central nervous system and glial cells, where it contributes to the regulation of neuronal signaling and support. Abnormalities in Cx33 expression or function have been linked to various neurological disorders, highlighting its importance in brain health and function.