Connexins are a family of proteins that form channels called gap junctions between adjacent cells. These channels allow for the direct transfer of ions and small molecules, facilitating communication and coordination between cells in various tissues, including the heart, brain, and skin. Each connexin protein has a specific structure and function, with different types expressed in different tissues. The most common types include Cx43, Cx32, and Cx26. Proper functioning of connexins is crucial for maintaining tissue homeostasis, and their dysfunction can lead to various diseases, including cardiac arrhythmias and neurological disorders.