"Custer's Last Stand" refers to the Battle of the Little Bighorn, fought on June 25-26, 1876. This battle was part of the Great Sioux War, where the U.S. Army aimed to force the Sioux and Cheyenne tribes onto reservations. General George Armstrong Custer led the 7th Cavalry against a large coalition of Native American warriors. Custer underestimated the strength and numbers of the Native American forces, which included leaders like Sitting Bull and Crazy Horse. The battle resulted in a decisive victory for the Native Americans, leading to the death of Custer and most of his men, marking a significant moment in U.S. history.