Chronic Limb Ischemia (CLI) is a condition characterized by reduced blood flow to the limbs, often due to narrowed or blocked arteries. This decreased circulation can lead to pain, ulcers, or even tissue death, primarily affecting the legs and feet. CLI is commonly associated with peripheral artery disease (PAD) and is more prevalent in individuals with risk factors such as diabetes, smoking, and high blood pressure. Symptoms of CLI include pain during physical activities, such as walking or climbing stairs, which typically eases with rest. In severe cases, individuals may experience pain at rest or develop non-healing wounds. Early diagnosis and treatment are crucial to prevent complications, including the need for amputation. Treatment options may include lifestyle changes, medications, or surgical interventions to restore blood flow.