Charles, Duke of Bourbon (1490-1527), was a prominent French nobleman and military leader during the early 16th century. He was a member of the powerful Bourbon family and played a significant role in the political landscape of France. Charles initially served King Francis I but later became a rival, leading to his defection to the Holy Roman Empire. In 1521, Charles was appointed as the commander of the Imperial forces against France. He is best known for his leadership during the Sack of Rome in 1527, which marked a pivotal moment in the Italian Wars. His actions significantly impacted the power dynamics in Europe during that era.