Catherine de La Trémoille (c. 1490–1549) was a French noblewoman known for her influential role in the politics of the early 16th century. She was the daughter of Louis de La Trémoille, a prominent noble, and became the wife of Antoine de Bourbon, which strengthened her family's political alliances. Catherine was a key figure during the French Wars of Religion, advocating for the interests of her family and the House of Bourbon. Her life was marked by her efforts to navigate the complex political landscape of France, particularly during a time of significant religious and civil strife.