Calyampudi Radhakrishna Rao, often referred to as C.R. Rao, is an esteemed Indian statistician born on September 10, 1920. He is renowned for his significant contributions to the fields of statistics and mathematics, particularly in the development of statistical theory and methods. His work has influenced various areas, including economics, biostatistics, and machine learning. Rao has authored numerous research papers and books, and he is known for the Cramér-Rao bound, a fundamental result in estimation theory. Throughout his career, he has received several prestigious awards, including the Padma Bhushan and the National Medal of Science, recognizing his impact on the discipline of statistics.