Cairo, Illinois, is a small city located at the confluence of the Mississippi River and the Ohio River. It serves as a significant transportation hub due to its strategic location, which has historically made it an important port city. Founded in the early 19th century, Cairo was once a bustling center for trade and commerce. Today, Cairo has a population of around 1,500 residents and is known for its rich history and diverse culture. The city features several historic sites, including the Cairo Custom House and the Fort Defiance Park, which attract visitors interested in the area's past.