C-type Lectin Receptors (CLRs) are a group of proteins that play a crucial role in the immune system. They recognize specific carbohydrates on the surfaces of pathogens, such as bacteria and fungi, helping the body identify and respond to infections. CLRs are primarily found on immune cells like dendritic cells and macrophages, where they facilitate the uptake and processing of antigens. These receptors are named "C-type" because they require calcium ions to bind to their carbohydrate ligands. By activating various signaling pathways, CLRs can influence immune responses, including inflammation and adaptive immunity. Their function is essential for maintaining the body's defense against infectious diseases.